This analysis was conducted to assess the impact of Coca-Cola on orthodontic materials compared to that of other fluids. Electronical searches were carried out in PubMed, Livivo, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov, supplemented by manual searches in the reference lists of the articles selected for full text evaluation. The risk of bias was assessed on the basis of a “risk of bias summary.” A total of 216 bibliographic summaries of articles were obtained, eleven of which were relevant. Nine of these papers showed a low risk, while two publications from one in vivo study exhibited a high risk of bias. The continuing influence of Coca-Cola caused significant discoloration of elastomeric materials and resulted in significantly lower shear bond strength of the brackets and higher corrosion. With regard to orthodontic appliances, additional in situ and in vivo studies are desirable. Special attention should be paid to an appropriate number of samples or patients, as most investigations lacked a sufficient number of test subjects. In addition, investigations with long observation periods and documented beverage consumption should be preferred. The intake of cola-containing beverages during orthodontic therapy and the exposure duration of these beverages to orthodontic material should be reduced to a minimum, as this can impair the adhesive strength and lead to corrosion of orthodontic brackets. The interval between orthodontic appointments should be short to avoid discoloration of orthodontic elastomeric ligatures.

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