Evaluation of Implant Survival in Xenograft-Grafted Sites
A Retrospective Study in a French Population
DOI:
https://doi.org/10.61872/sdj-2025-02-06PMID:
40574543Keywords:
peri-implantitis, implant survival, xenograft, bone lossAbstract
Patients with a history of periodontitis often require bone augmentation prior to implant placement; however, the mid-term outcomes of implants in augmented sites are not well documented. The aim of this retrospective study was to evaluate the mid-term survival and peri-implant health of implants placed in xenograft-augmented sites in patients with a history of periodontitis. Records of 34 patients (mean age: 65.3 ± 12 years; 64.7% Stage III, 29.4% Stage IV periodontitis) treated at the University of Strasbourg between 2015 and 2023 were analyzed, including 62 implants placed in xenograft-augmented sites. The mean follow-up was 5.74 ± 2.3 years. No implant failures occurred, yielding a 100% survival rate. The mean probing depth was 2.98 mm, and bleeding on probing averaged 25.5%. Marginal bone loss averaged 0.86 mm (distal) and 0.87 mm (mesial), corresponding to an annual bone loss of 0.18 mm; the most frequent bone loss pattern was vertical (71%). No peri-implantitis was observed; 54.8% of implants presented peri-implant mucositis, and 45.2% were classified as healthy. Within the limitations of this study, implants placed in xenograft-augmented sites in periodontally compromised patients demonstrated excellent mid-term survival and peri-implant tissue stability.
References
1. Berglundh T, Armitage G, Araujo MG, Avila-Ortiz G, Blanco J, Camargo PM, et al. Peri-implant diseases and conditions: Consensus re-port of workgroup 4 of the 2017 World Work-shop. J Clin Periodontol. 2018;45(S20):S286–91.
2. Herrera D, Berglundh T, Schwarz F, Chapple I, Jepsen S, Sculean A, Kebschull M, Papapa-nou PN, Tonetti MS, Sanz M; EFP workshop partici-pants and methodological consultant. Preventi-on and treatment of peri-implant diseases-The EFP S3 level clinical practice gui-deline. J Clin Pe-riodontol. 2023 Jun;50 Suppl 26:4-76.
3. Tenenbaum H, Bogen O, Séverac F, Elkaim R, Davideau JL, Huck O. Long-term prospec-tive cohort study on dental implants: clinical and microbiological parameters. Clin Oral Implants Res. 2017;28(1):86–94.
4. Schwarz F, Sahm N, Becker J. Impact of the outcome of guided bone regeneration in de-hiscence-type defects on long-term peri-implant health: observations at 4 years. Clin Oral Im-plants Res. 2012;23(2):191–6.
5. Diaz P, Gonzalo E, Villagra LJG, Miegimolle B, Suarez MJ. What is the prevalence of peri-implantitis? A systematic review and meta-analysis. BMC Oral Health. 2022;22(1):449.
6. Vagia P, Papalou I, Burgy A, Tenenbaum H, Huck O, Davideau JL. Association between peri-odontitis treatment outcomes and peri-implantitis: A retrospective study. Clin Oral Im-plants Res. 2021;32(6):721–31.
7. Sarbacher A, Papalou I, Vagia P, Tenenbaum H, Huck O, Davideau JL. Risk assessment scores and peri-implantitis prediction in patients trea-ted for periodontal disease: a long-term study. J Clin Med. 2022;11(6):1720.
8. Karoussis IK, Salvi GE, Heitz-Mayfield LJA, Brägger U, Hämmerle CHF, Lang NP. Long-term implant prognosis in patients with and without a history of chronic periodontitis: a 10-year cohort study. Clin Oral Implants Res.2003;14(3):329–39.
9. Papalou I, Vagia P, Cakir A, Tenenbaum H, Huck O, Davideau JL. Influence of periodonti-tis, implant, and prosthesis characteristics on peri-implant status: a cross-sectional stu-dy. Int J Dent. 2022;2022:9984871.
10. Dioguardi M, Cantore S, Quarta C, Sovereto D, Zerman N, Pettini F, Muzio LL, Cosola MD, Santacroce L, Ballini A. Correlation between Di-abetes Mellitus and Peri-implantitis: A Systema-tic Review. Endocr Metab Immune Disord Drug Targets. 2023;23(5):596-608.
11. Petit C, Schmeltz S, Burgy A, Tenenbaum H, Huck O, Davideau JL. Risk factors and tooth loss after periodontal therapy: influence of compli-ance definitions. Clin Oral Investig. 2019;23(11):4123–31.
12. Costa FO, Lages EJP, Cortelli SC, et al. Associati-on between cumulative smoking expo-sure, smoking cessation, and peri-implantitis: a cross-sectional study. Clin Oral Investig. 2022;26(7):4835–46.
13. Diaz P, Gonzalo E, Villagra LJG, Miegimolle B, Suarez MJ. What is the prevalence of peri-implantitis? A systematic review and meta-analysis. BMC Oral Health. 2022 Oct 19;22(1):449.
14. French D, Ofec R, Levin L. Long-term perfor-mance of 10,871 dental implants: a cohort stu-dy with 22-year follow-up. Clin Implant Dent Re-lat Res. 2021;23(3):289–97.
15. Hammerle CH, Jung RE, Lussi A. Bone augmen-tation procedures in implant dentistry. J Clin Pe-riodontol. 2004;31(S5):31–46.
16. Benic GI, Hämmerle CHF. Horizontal bone aug-mentation by guided bone regeneration. Perio-dontol 2000. 2014;66(1):13–40.
17. Zhao R, Yang R, Cooper PR, et al. Bone grafts and substitutes in dentistry: current trends and developments. Molecules. 2021;26(10):3007.
18. Ferraz MP. Bone grafts in dental medicine: an overview of autografts, allografts and synthetic materials. Materials (Basel). 2023;16(11):4117.
19. Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, et al. Periodontitis: Consen-sus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Pe-riodontol. 2018;89(S1):S173–82.
20. Carra MC, Blanc-Sylvestre N, Courtet A, Bouchard P. Primordial and primary prevention of peri-implant diseases: A systematic review and meta-analysis. J Clin Periodontol. 2023 Jun;50 Suppl 26:77-112.
21. Titsinides S, Agrogiannis G, Karatzas T. Bone grafting materials in dentoalveolar recons-truction: A comprehensive review. Jpn Dent Sci Rev. 2019;55(1):26-32.
22. Win KZ, Pimkhaokham A, Kaboosaya B. Com-paring Bone Graft Success, Implant Survival Ra-te, and Marginal Bone Loss: A Retrospective Study on Materials and Influential Fac-tors. J Oral Implantol. 2024;50(4):300-7.
23. Heitz-Mayfield LJ. Peri-implant diseases: diag-nosis and risk indicators. J Clin Periodontol. 2008;35(8 Suppl):292-304.
24. Rosen P, Clem D, Cochran D, Froum S, McAllis-ter B, Renvert S, Wang HL. Peri-implant mucosi-tis and peri-implantitis: A current understanding of their diagnoses and clinical implications. J Pe-riodontol. 2013;84:436–43.
25. Derks J, Tomasi C. Peri-implant health and dise-ase. A systematic review of current epi-demiology. J Clin Periodontol. 2015;42(Suppl 16):S158–S71.
26. Vercruyssen M, Quirynen M. Long-term, ret-rospective evaluation (implant and patient-centred outcome) of the two-implant-supported overdenture in the mandible. Part 2: marginal bone loss. Clin Oral Implants Res. 2010;21(5):466–72.
27. Schwarz F, Derks J, Monje A, Wang HL. Peri-implantitis. J Clin Periodontol. 2018;45(Suppl 20):S246–S66.
28. Katafuchi M, Weinstein BF, Leroux BG, Chen YW, Daubert DM. Restoration contour is a risk indicator for peri-implantitis: A cross-sectional radiographic analysis. J Clin Periodon-tol. 2018;45(2):225–32.
29. Becker ST, Beck-Broichsitter BE, Rossmann CM, Behrens E, Jochens A, Wiltfang J. Long-term Survival of Straumann Dental Implants with TPS Surfaces: A Retrospective Study with a Follow-up of 12 to 23 Years. Clin Implant Dent Relat Res. 2016;18(3):480–8.
30. Aghaloo TL, Moy PK. Which hard tissue aug-mentation techniques are the most suc-cessful in furnishing bony support for implant place-ment? Int J Oral Maxillofac Implants. 2007;22(Suppl):49–70.
31. Monje A, Insua A, Wang HL. Association of systemic conditions with peri-implantitis: a nar-rative review. J Clin Periodontol. 2019;46(Suppl 21):S26–S41.
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Copyright (c) 2025 Lina Tahour, Olivier Huck, Kamer Kurumal, Pierre-Yves Gegout, Catherine Petit

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