Autologous platelet concentrates in regenerative dentistry – A narrative literature review : Part I: Theoretical and legal aspects of the PR(G)F application

Oliver P. Ernst; Liza L. Ramenzoni; Patrick R. Schmidlin

doi:10.61872/sdj-2024-05-02

Authors

Oliver P. Ernst Klinik für Zahnerhaltung und Präventivzahnmedizin, Bereich für Parodontologie und Periimplantäre Erkrankungen, Zentrum für Zahnmedizin, Universität Zürich, Zürich, Schweiz, und Privatpraxis, Zürich, Schweiz
Liza L. Ramenzoni Klinik für Zahnerhaltung und Präventivzahnmedizin, Bereich für Parodontologie und Periimplantäre Erkrankungen, Zentrum für Zahnmedizin, Universität Zürich, Zürich, Schweiz
Patrick R. Schmidlin Klinik für Zahnerhaltung und Präventivzahnmedizin, Bereich für Parodontologie und Periimplantäre Erkrankungen, Zentrum für Zahnmedizin, Universität Zürich, Zürich, Schweiz

DOI:

https://doi.org/10.61872/sdj-2024-05-02

PMID:

38741455

Keywords:

Autologe Plättchenkonzentrate, Autologe Thrombozytenkonzentrate, Plasma rich in growth factors, Platelet rich fibrin, Regeneration

Abstract

The use of autologous platelet concentrates (APC) such as platelet-rich fibrin (PRF) and/or plasma rich in growth factors (PRGF.) is considered an established treatment modality in regenerative dentistry. The possibility of delivering growth factors over a clinically relevant time of several days seems particularly interesting in the context of wound healing. The growing body of evidence in the field of APC requires a continuous and actual knowledge of the literature for being able to make evidence-based treatment recommendations with a realistic assessment of possible advantages of this technology. PR(G)F can be applied in solid or liquid form, pure or in combination with other biomaterials. Both appear to be reasonable, depending on the clinical indication and/or desired treatment outcomes. Because of the many different factors that can affect the PR(G)F products final characteristics, a basic understanding of these parameters is desirable for choosing the most suitable product and/or optimizing its clinical application. This review aims to provide an overview of relevant theoretical, practical, legal and biologic aspects of APCs.

References

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Autologous platelet concentrates in regenerative dentistry – A narrative literature review. Part I: Theoretical and legal aspects of the PR(G)F application

Part I: Theoretical and legal aspects of the PR(G)F application

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