Respiratory diseases are associated with molar-incisor hypomineralizations

Authors

  • Jan Kühnisch Department of Conservative Dentistry and Periodontology, School of Dentistry, Ludwig-Maximilians University of Munich, Munich, Germany
  • Daniela Mach Department of Conservative Dentistry and Periodontology, School of Dentistry, Ludwig-Maximilians University of Munich, Munich, Germany
  • Elisabeth Thiering Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany; Institute of Medical Data Management, Biometrics and Epidemiology, Ludwig-Maximilians University of Munich, Munich, Germany
  • Inken Brockow Department of Pediatrics, Technical University of Munich, Munich, Germany
  • Ute Hoffmann Department of Pediatrics, Technical University of Munich, Munich, Germany
  • Claudia Neumann Department of Conservative Dentistry and Periodontology, School of Dentistry, Ludwig-Maximilians University of Munich, Munich, Germany
  • Roswitha Heinrich-Weltzien Department of Preventive and Pediatric Dentistry, Friedrich-Schiller University of Jena, Jena, Germany
  • Carl-Peter Bauer Department of Pediatrics, Technical University of Munich, Munich, Germany
  • Dietrich Berdel Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany
  • Andrea von Berg Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany
  • Sybille Koletzko Dr von Hauner Children’s Hospital, Ludwig-Maximilians University of Munich, Munich, Germany
  • Franklin Garcia-Godoy Bioscience Research Center, College of Dentistry, University of Tennessee, Memphis, Tennessee, USA, and Department of Conservative Dentistry and Periodontology, Ludwig-Maximilians University of Munich, Germany
  • Reinhard Hickel Department of Conservative Dentistry and Periodontology, School of Dentistry, Ludwig-Maximilians University of Munich, Munich, Germany
  • Joachim Heinrich Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
  • GINI plus 10 Study Group The GINI plus 10 study group are: Heinrich J, Wichmann H E, Schoetzau A, Popescu M, Franke K, Laubereau B, Sausenthaler S, Zutavern A, Filipiak B, Gehring U, Chen C M (Institute of Epidemiology, Helmholtz Zentrum Muenchen, National Research Center for Environmental Health, Munich, Germany); Berdel D, von Berg A, Bollrath C, Groß I (Department of Pediatrics, Marien-Hospital, Wesel, Germany); Koletzko S, Reinhard D, Weigand H (Dr von Hauner Children’s Hospital, Ludwig-Maximilians University of Munich, Munich, Germany); Bauer C P, Grübl A, Bartels P, Brockow I, Hoffmann U (Department of Pediatrics, Technical University of Munich, Munich, Germany) and Krämer U, Link E, Sugiri D, Ranft U (IUF-Environmental Health Research Institute, Düsseldorf, Germany)

DOI:

https://doi.org/10.61872/sdj-2014-03-01

PMID:

24671727

Keywords:

molar-incisor hypomineralization, enamel hypomineralizations, etiology, birth cohort study, epidemiology

Abstract

The objective of our study was to evaluate the association of molar-incisor hypomineralizations (MIHs) with prospectively collected potential causative factors from the first 4 years of life, e.g. respiratory diseases, breastfeeding, maternal smoking and parental education. A total of 692 children (10 years old) from the GINI birth cohort study participated. The dental examination included the registration of enamel hypomineralizations (EHs) according to the EAPD criteria. Children with EH were sub-categorized into those with at least one EH (MIH/1), those with a minimum of one EH on at least one first permanent molar (MIH/2) and those with EH on at least one first permanent molar and a permanent incisor (MIH/3). All relationships between causative factors and caries or MIH were evaluated using simple and multiple logistic regression analyses. EHs were observed in 37.9% (MIH/1), 14.7% (MIH/2) and 9.2% (MIH/3) of all subjects. After adjustment for confounding factors, 10-year-old children with at least one episode of respiratory disease had a significantly higher risk (2.48 times, adjusted OR) for the development of MIH/3. In case of breastfeeding, a non-significant association was observed. None of the tested factors was associated with either MIH/1 or MIH/2. Early respiratory diseases seem to be directly or indirectly related to MIH/3 only. The role of (systemic) medications used for treatment of these diseases needs to be investigated in future studies.

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Published

2014-03-17

How to Cite

Kühnisch, J., Mach, D., Thiering, E., Brockow, I., Hoffmann, U., Neumann, C., Heinrich-Weltzien, R., Bauer, C.-P., Berdel, D., von Berg, A., Koletzko, S., Garcia-Godoy, F., Hickel, R., Heinrich, J., & plus 10 Study Group, G. (2014). Respiratory diseases are associated with molar-incisor hypomineralizations. SWISS DENTAL JOURNAL SSO – Science and Clinical Topics, 124(3), 286-93. https://doi.org/10.61872/sdj-2014-03-01

How to Cite

Kühnisch, J., Mach, D., Thiering, E., Brockow, I., Hoffmann, U., Neumann, C., Heinrich-Weltzien, R., Bauer, C.-P., Berdel, D., von Berg, A., Koletzko, S., Garcia-Godoy, F., Hickel, R., Heinrich, J., & plus 10 Study Group, G. (2014). Respiratory diseases are associated with molar-incisor hypomineralizations. SWISS DENTAL JOURNAL SSO – Science and Clinical Topics, 124(3), 286-93. https://doi.org/10.61872/sdj-2014-03-01